Patent
1. Le Zhang, Tingting Li, Nan Hu, Xiaoyu He. A gene, singaling pathway and related protein slection algorihtm for hign dimension low sample data. Vol. ZL 2016 1 0734417. X (China, 2016).

2. Le Zhang, Meijing Kong. A confirmation method of myeloma signaling pathway mechanism based on modular factor graph. 201610846098.1 (China, 2016).

3. Le Zhang. A analytical method for colorectal cancer data model based on genetic and environmental correlation. 201610953314.2 (China, 2016).

4. Le Zhang, Hongjie Gao. A multi-scale drug coordination prediction method based on Agent. ZL  2017 1 156248.7 (China, 2017).

5. Le Zhang, Ming Xiao. The method and system for multi-species unappeared k-mer subsequence calculating and characteristic analysis. ZL 2018 1 0207512.3 (China, 2018).

6. Le Zhang, Jingxing Chen, Weilong Ding, Chenyang Jing, Jiping Feng. The codon bias coefficient model method based on CPU-GPU heterogeneous composite parallel computing framework. China patent ZL 2017 1 0332575.7. 2017.

Research Papers
1. Zhang L*, Liu G, Kong M, Li T, Wu D, Zhou X, et al. Revealing dynamic regulations and the related key proteins of myeloma-initiating cells by integrating experimental data into a systems biological model. Bioinformatics. 2019. doi: 10.1093/bioinformatics/btz542. PubMed PMID: 31350562. (IF: 5.481)
2. Zhang L*, Li J, Yin K, Jiang Z, Li T, Hu R, et al. Computed tomography angiography-based analysis of high-risk intracerebral haemorrhage patients by employing a mathematical model. BMC Bioinformatics. 2019;20(Suppl 7):193. doi: 10.1186/s12859-019-2741-5. PubMed PMID: 31074379; PubMed Central PMCID: PMCPMC6509873. (IF: 2.511)
3. Zhang L, Fu C, Li J, Zhao Z, Hou Y, Zhou W, et al. Discovery of a Ruthenium Complex for the Theranosis of Glioma through Targeting the Mitochondrial DNA with Bioinformatic Methods. International Journal of Molecular Sciences. 2019;20(18):4643. doi: 10.3390/ijms20184643. (IF: 4.183)
4. Zhang L, Dai Z, Yu J, Xiao M. CpG-Island-based annotation and analysis of human house-keeping genes. Briefs in Bioinformatics. 2019;( ): . Epub doi: 10.1093/bib/bbz134. PubMed PMID: . (IF: 9.101)
5. Zhang L*, Bai W, Yuan N, Du Z. Comprehensively benchmarking applications for detecting copy number variation. PLoS Comput Biol. 2019;15(5):e1007069. doi: 10.1371/journal.pcbi.1007069. PubMed PMID: 31136576; PubMed Central PMCID: PMCPMC6555534 Zdmedical, Information Polytron Technologies Inc. (IF:4.428)
6. Xiao M, Yang X, Yu J, Zhang L*. CGIDLA: Developing the Web Server for CpG Island related Density and LAUPs (Lineage-associated Underrepresented Permutations) Study. IEEE/ACM Trans Comput Biol Bioinform. 2019. doi: 10.1109/TCBB.2019.2935971. PubMed PMID: 31443042. (IF: 2.896)
7. Liu G-D, Li Y-C, Zhang W, Zhang L*. A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders. Engineering. 2019. doi: 10.1016/j.eng.2019.06.008. (IF:4.568)
8. Zhang L*, Xiao M, Zhou J, Yu J. Lineage-associated underrepresented permutations (LAUPs) of mammalian genomic sequences based on a Jellyfish-based LAUPs analysis application (JBLA). Bioinformatics. 2018;34(21):3624-30. Epub 2018/05/16. doi: 10.1093/bioinformatics/bty392. PubMed PMID: 29762634. (IF:7.703)
9. Zhang L*, Zheng CQ, Li T, Xing L, Zeng H, Li TT, et al. Building Up a Robust Risk Mathematical Platform to Predict Colorectal Cancer. Complexity. 2017;2017:14. doi: Artn 8917258 10.1155/2017/8917258. PubMed PMID: WOS:000414092700001. (IF 4.621)
10. Zhang L*, Zhang S. Using game theory to investigate the epigenetic control mechanisms of embryo development: Comment on: "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al. Phys Life Rev. 2017;20:140-2. Epub 2017/01/23. doi: 10.1016/j.plrev.2017.01.007. PubMed PMID: 28109753. (IF 13.84)
11. Zhang L*, Liu Y, Wang M, Wu Z, Li N, Zhang J, et al. EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients. J Mol Cell Biol. 2017;9(6):477-88. Epub 2017/12/23. doi: 10.1093/jmcb/mjx056. PubMed PMID: 29272522; PubMed Central PMCID: PMCPMC5907834. (IF 5.988)
12. Zhang L*, Qiao M, Gao H, Hu B, Tan H, Zhou X, et al. Investigation of mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model and experimental optimization/validation. Nanoscale. 2016;8(31):14877-87. Epub 2016/07/28. doi: 10.1039/c6nr01637e. PubMed PMID: 27460959. (IF 7.36)